UCI Scientists Develop Humanized Mice For Studying Alzheimer’s Disease
Neurology and behavior associate professor Mathew Blurton-Jones says that microglia, a type of brain cell, can play a crucial role in how Alzheimer’s develops and progresses. He explains that there are 40-plus genes that are linked to the neurodegenerative disease and most of them are found within the microglia. Up until now, scientists have only been able to study them in end-stage Alzheimer’s in labs or post-mortem.
The chimeric model uses mice for human brain cells via special induced pluripotent stem cells donated by human patients. The stem cells were coaxed into turning into microglia which were then implanted in genetically modified mice.
The new chimeric model may finally unlock the secrets of immune cells in terms of brain development and in treating many types of neurological disorders.
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