Stem-cell based therapy for type 2 diabetes and obesity
In China’s Jiao Tong University and Ninth People’s Hospital in Shanghai, a group of researchers spearheaded by professor Bing Wang have concluded a successful transplantation of MSCs, or mesenchymal stem cells, derived from adipose tissue which reduces inflammation and provides metabolic balance in animals.
Diabetes is considered as a global epidemic. The World Health Organization says that people suffering from T2D, or type 2 diabetes, is currently around 347 million. In T2D, patients develop insulin resistance which invariably makes blood sugar levels rise. Over time, high blood sugar can damage the kidneys, nerves, eyes and the heart. Obesity is considered one of the biggest markers in type 2 diabetes.
In the preliminary study, the mesenchymal stem cells improved the metabolic capacity of patients who were suffering from T2D. MSCs derived from adipose tissue are in abundant supply and can be collected via minimally invasive processes.
Dr. Wang and the research team experimented on mice that were given a high-fat diet. The batch that received ADSCs, or adipose derived stem cells showed sensitivity to insulin and had reduced blood sugar levels. Stem cells that had more neuregulin 4 proved to be the best in reducing insulin and blood glucose resistance.
Dr. Wang mentioned that the study showed how neuregulin overexpression may have accelerated the efficacy of the adipose derived mesenchymal stem cells towards metabolic disorders and insulin resistance that are common in people with type 2 diabetes.
Experimental Biology & Medicine Editor in Chief Dr. Steven Goodman, mentioned that Wang and team have added a possible therapeutic option for patients suffering from obesity and type 2 diabetes. He also said that MSCs that have increased neuregulin 4 markers were successful in reducing insulin and blood glucose resistance in high-fat diet mice.
If the future trials prove to be effective, then a new possible treatment for T2D should surface.
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